Publications

  1. Hayer, S., Mandelbaum, A.D., Watch, L., Ryan, K.S., Hedges, M.A., Manuzak, J.A., Easley IV, C.A., Schust, D.J., Lo, J.O. (2024). “Cannabis and Pregnancy: A Review.” Obstetrical and Gynecological Survey.

  2. Shorey-Kendrick, L. E., V. H. J. Roberts, R. J. D’Mello, E. L. Sullivan, S. K. Murphy, O. J. T. McCarty, D. J. Schust, J. C. Hedges, A. J. Mitchell, J. J. D. Terrobias, C. A. Easley, E. R. Spindel and J. O. Lo (2023). “Prenatal delta-9-tetrahydrocannabinol exposure is associated with changes in rhesus macaque DNA methylation enriched for autism genes.” Clin Epigenetics.
  3. Jason C. Hedges, Carol B. Hanna, Lyndsey E. Shorey-Kendrick, Emily R. Boniface, Jasper C. Bash, Travis L. Rice-Stitt, Fernanda C. Burch, Rahul D’Mello, Terry K. Morgan, Ana Cristina Lima, Juanito Jose D. Terrobias, Jason A. Graham, Emily C. Mishler, Jared V. Jensen, Olivia L. Hagen, J. Wes Urian, Eliot R. Spindel, Charles A. Easley IV, Susan K. Murphy, Jamie O. Lo. (2023) Cessation of chronic delta-9-tetrahydrocannabinol use partially reverses impacts on male fertility and the sperm epigenome in rhesus macaques. Fertility and Sterility. 
  4. Katherine W. Greeson, Krista M.S. Crow, R. Clayton Edenfield, and Charles A. Easley IV. (2023) Inheritance of paternal lifestyles and exposures through sperm DNA methylation. Nature Reviews Urology. 
  5. Rose Schrott, Katherine W. Greeson, Dillon King, Krista M. Symosko Crow, Charles A. Easley IV, Susan K. Murphy. (2022) Cannabis alters DNA methylation at maternally imprinted and autism candidate genes in spermatogenic cells, Systems Biology in Reproductive Medicine.
  6. Shuo Xiao, Krista M. Symosko, Charles A. Easley IV. (2022) Reproductive and Developmental Toxicity: Toxic Effects on the Female and Male Reproductive Tracts and Offspring. In: Roberts SM.,James RC., Williams PL. (eds) Principles of Toxicology: Environmental and Industrial Applications. Wiley. LCNN 2021060413
  7. Cho, I. K., Easley, C. A., & Chan, A. W. (2022). Suppression of trinucleotide repeat expansion in spermatogenic cells in Huntington’s disease. Journal of assisted reproduction and genetics, 39(10), 2413-2430.
  8. Lawlor, M., Zigo, M., Kerns, K., Cho, I. K., Easley IV, C. A., & Sutovsky, P. (2022). Spermatozoan Metabolism as a Non-Traditional Model for the Study of Huntington’s Disease. International Journal of Molecular Sciences, 23(13), 7163.
  9. Clewell RA, Clewell III HJ, Linkas MW, Easley CA, Langmo JN, Salley J, Gentry R, Rucker T. An in vitro approach to determine the human relevance of anti-spermatogenic effects of 4-mthylmorpholine 4- oxide, monohydrate (NMMO) in rat reproductive toxicity studies. Apr 19 2022. Toxicology in vitro. doi: https://doi.org/10.1016/j.tiv.2022.105365
  10. Hedges JC, Hanna CB, Bash JC, Boniface ER, Burch FC, Mahalingaiah S, Roberts VHJ, Terrobias JJD, Mishler EC, Jensen JV. Easley CA, Lo JO. Chronic exposure to delta-9-tetrahydrocannabinol impacts testicular volume and male reproductive health in rhesus macaques. Jan 25 2022. Fertility and Sterility. doi: https://doi.org/10.1016/j.fertnstert.2021.12.028
  11. Symosko K.M., Schatten G., Easley C.A. (2022) Gamete Production from Stem Cells. In: Grynberg M., Patrizio P. (eds) Female and Male Fertility Preservation. Springer, Cham. https://doi.org/10.1007/978-3-030-47767-7_32
  12. Atwi K, Wilson S, Mondal A, Edenfield RC, Symosko Crow KM, El Hajj O, Perrie C, Glenn CK, Easley CA, Handa H, Saleh R. Differential response of human lung epithelial cells to particulate matter in fresh and photochemically aged biomass-burning smoke. Dec 31 2021. Atmospheric Environment. doi: https://doi.org/10.1016/j.atmosenv.2021.118929.
  13. Khampang S, Cho IK, Punyawai K, Langmo J, Gill B, Symosko KM, Fowler KL, Greeson KW, Tian S, Steves AN, Parnpai R, Statz J, Hennebold JD, Orwig KE, Simerly CR, Schatten GP, Chan AWS, Easley CA.† Blastocyst Development after Fertilization with in vitro Spermatids Derived from Non-Human Primate Embryonic Stem Cells. Sept 7 2021. Fertility and Sterility Science. doi:10.1016/j.xfss.2021.09.001. PMID: 34970648
  14. Edenfield RC and Easley CA†. Implications of testicular ACE2 and the renin-angiotensin system for SARS-CoV-2 on testis function. Nat Rev Urol. 2021. Nov 26: 1-12. doi: 10.1038/s41585-021-00542-5. PMID: 34837081 
  15. Khampang S, Parnpai R, Mahikul W, Easley CA, Cho IK, Chan AWS. CAG Repeat Instability in Embryonic Stem Cells and Derivative Spermatogenic Cells of Transgenic Huntington’s Disease Monkey. Journal of Assisted Reproduction and Genetics. 2021 Feb 20. doi: 10.1007/s10815-021-02106-3. Online ahead of print. PMID: 33611676
  16. Correll-Tash S, Lilley B, Salmons H, Mlynarski E, Franconi CP, McNamara M, Woodbury C, Easley CA, Emanuel BS. Double Strand Breaks as Indicators of Genomic Instability in PATRR-mediated Translocations. Hum Mol Genet. 2020 Dec 1:ddaa251. doi: 10.1093/hmg/ddaa251. Online ahead of print. PMID: 33258468
  17. Greeson KW, Fowler KL, Estave PM, Thompson SK, Wagner CR, Edenfield RC, Symosko KM, Steves AN, Marder EM, Terrell ML, Barton H, Marcus M, Koval M, Easley CA. † Detrimental Effects of Flame Retardant, PBB153, Exposure on Sperm and Future Generations. Scientific Reports. 2020 May 22;10(1):8567. doi: 10.1038/s41598-020-65593-x. PMID: 32444626
  18. Steves AN, Bradner JM, Fowler KL, Clarkson-Townsend D, Gill B, Turry A, Caudle WM, Miller GW, Chan AW, Easley CA. †. Ubiquitous Environmental Toxicants Impair Spermatogenesis in a Human Stem Cell Model. iScience. 2018 May 25;3:161-176. doi: 10.1016/j.isci.2018.04.014. PMID: 29901031
  19. Steves AN, Turry A, Gill B, Clarkson-Townsend D, Bradner JM, Bachli I, Caudle WM, Miller GW, Chan AW, Easley CA. †. Per- and Polyfluoroalkyl Substances Impact Human Spermatogenesis in a Stem Cell Derived Model. Syst Biol Reprod Med. 2018 Aug;64(4):225-239. doi: 10.1080/19396368.2018.1481465. Epub 2018 Jun 18. PMID: 29911897.
  20. Holler CJ, Taylor G, McEachin ZT, Deng Q, Watkins WJ, Hudson K, Easley CA, Hu WT, Hales CM, Rossoll W, Bassell GJ, Kukar T. Trehalose upregulates progranulin expression in human and mouse models of GRN haploinsufficiency: a novel therapeutic lead to treat frontotemporal dementia. Mol Neurodegener. 2016 Jun 24;11(1):46. doi: 10.1186/s13024-016-0114-3. PMID: 27341800
  21. Easley IV CA, Bradner JM, Moser A, Rickman CA, McEachin ZT, Merritt M, Hansen JM and Caudle WM. Assessing Reproductive Toxicity of Environmental Toxicants with a Novel in vitro Human Spermatogenic Model. Stem Cell Res. 2015 Mar 25;14(3):347-355. doi: 10.1016/j.scr.2015.03.002. PMID: 25863443
  22. Gokhale A, Mullin AP, Zlatic SA, Easley IV CA, Merritt ME, Raj N, Larimore J, Gordon DE, Peden AA, Sanyal S and Faundez V. NSF Acts Downstream of the Schizophrenia Susceptibility Factor, Dysbindin, to Regulate Synaptic Homeostasis. J Neurosci. 2015 May 13;35(19):7643-53. doi: 10.1523/JNEUROSCI.4724-14.2015. PMID: 25972187
  23. Easley IV CA, Simerly CR, Schatten GP. Gamete derivation from embryonic stem cells, induced pluripotent stem cells or somatic cell nuclear transfer-derived embryonic stem cells: state of the art. Reprod Fertil Dev. 2014 Dec;27(1):89-92. doi: 10.1071/RD14317. PMID: 25472048
  24. Nguyen DC, Hookway TA, Wu Q, Jha R, Preininger MK, Chen X, Easley CA, Spearman P, Deshpande SR, Maher K, Wagner MB, McDevitt TC and Xu C. Microscale Generation of Cardiospheres Promotes Robust Enrichment of Cardiomyocytes Derived from Human Pluripotent Stem Cells. Stem Cell Reports. Published online July 3 2014. DOI: http://dx.doi.org/10.1016/j.stemcr.2014.06.002
  25. Sherman SL, Curnow EC, Easley CA, Jin P, Hukema RK, Tejada MI, Willemsen R, Usdin K. Use of model systems to understand the etiology of fragile X-associated primary ovarian insufficiency (FXPOI). J Neurodev Disord. 2014;6(1):26. doi: 10.1186/1866-1955-6-26. Epub 2014 Aug 13. PMID: 25147583. PMCID: PMC4139715
  26. Easley IV CA, Simerly CR and Schatten GP. Direct Differentiation of Human Pluripotent Stem Cells into Advanced Spermatogenic Cells: In Search of an in vitro System to Model Male Factor Infertility. Springer Publication Proceedings for Virginia State University STEAM-H. Accepted Feb. 2014
  27. Easley IV CA, Latov DR, Simerly CR and Schatten GP. Adult Somatic Cells to the Rescue: Nuclear Reprogramming and the Dispensability of Gonadal Germ Cells. Invited Review. Fertility and Sterility. Fertil Steril. 2014 Jan;101(1):14-9. doi: 10.1016/j.fertnstert.2013.11.025. PMID: 24382340
  28. Easley IV CA, Simerly CR, Schatten G. Stem Cell Therapeutic Possibilities: Future Therapeutic Options for Male-factor and Female-factor Infertility? Reprod Biomed Online. 2013 Mar 26. doi:pii: S1472-6483(13)00129-6.10.1016/j.rbmo.2013.03.003. [Epub ahead of print] PMID: 23664220
  29. Easley IV CA, Phillips BT, Wu G, Schatten GP, and Simerly CR. Clinical Implications of Human Spermatogenesis Initiation In Vitro. Invited Review. Oct. 2012. Journal of Medical Sciences.
  30. Easley IV CA, Phillips BT, McGuire, MM, Barringer JM, Valli H, Hermann BP, Simerly CR, Miki T, Orwig KE, and Schatten GP. Direct Differentiation of Human Pluripotent Stem Cells into Haploid Spermatogenic Cells. Online, Aug 2012, print edition Sept 2012. Cell Reports.
  31. Easley IV CA*, Miki T*, Castro CA, Ozolek JA, Minervini CF, Ben-Yehudah A and Schatten GP. Human Amniotic Epithelial Cells are Reprogrammed More Efficiently by Induced Pluripotency than Adult Fibroblasts. Cellular Reprogramming. 2012 Jun;14(3): 193-203.
  32. Shweiki D, Ben-Yehudah A, Redinger C, Easley IV C, Doron S, and Schatten G. Sexually Dimorphic Gene Expression in Non-human Primate ESCs. Biochemical and Biophysical Research Communications. 2011 Oct 28;414(3) 631-634.
  33. Varum S, Rodrigues A, Moura M, Momcilovic O, Easley C, Ramalho-Santos J, Van Houten B and Schatten G. Energetic Metabolism of Human Pluripoten Stem Cells and Their Differentiated Counterparts. PLoS ONE. 2011:6(6): e20914.
  34. Momcilovic O, Knoblach L, Fornsaglio J, Varum S, Easley C, Schatten J. DNA Damage Responses in Human Induced Pluripotent Stem Cells and Embryonic Stem Cells. PLoS One 2010 Oct 15:5(10):e13410
  35. Ben-Yehudah A, Easley IV CA, Hermann B, Castro C, Simerly C, Orwig K, Mitalopov S, Schatten G. System Biology Discoveries Using Non-Human Primate Pluripotent Stem and Germ Cells:  Novel Gene and Genomic Imprinting Interactions As Well As Unique Expression Patterns. Stem Cell Research and Therapy 2010 Aug 5;1(3):24.
  36. Easley IV CA, Ben-Yehudah A, Redinger CJ, Oliver SL, Varum ST,  Eisinger V, Carlisle D, Donovan PJ and Schatten GP. mTOR-mediated Activation of p70 S6K Induces Differentiation of Pluripotent Human Embryonic Stem Cells. Cellular Reprogramming 2010 12;3.
  37. Rothschild SC, Easley CA, Francescatto L, Lister JA, Garrity DM and Tombes RM. Tbx5-mediated β2 CaMK-II Expression is Required for Heart Looping and Pectoral Fin Development. Dev Biol. 2009 Jun 1;330(1):175-84. Epub 2009 Apr 1.
  38. Easley CA, Brown CM, Horwitz AF and Tombes RM. CaMK-II Promotes Focal Adhesion Turnover and Cell Motility by Inducing Tyrosine Dephosphorylation of FAK and Paxillin. Cell Mot. And Cyto. 2008 Aug; 65(8); 662-674.
  39. Seward ME, Easley CA, McLeod JJ, Myers AL and Tombes RM. Flightless-I, a Gelsolin Family Member and Transcriptional Regulator, Preferentially Binds Directly to Activated Cytosolic CaMK-II. FEBS Letters. 2008 Jul 23; 582(17); 2489-2495.
  40. Easley CA, Faison MO, Kirsch TL, Lee JA, Seward ME and Tombes RM. Laminin Activates CaMK-II to Stabilize Nascent Embryonic Axons. Brain Res. 2006 May 30: 1092(1); 59-68.